@AdityaRajKaul
Important point to ponder. External Affairs Minister@DrSJaishankar on rise of nationalism says, ‘nationalism in Asia is a nationalism of confidence while nationalism in other places is a nationalism of insecurity’.
Partly collected thoughts.
@AdityaRajKaul
Important point to ponder. External Affairs Minister@DrSJaishankar on rise of nationalism says, ‘nationalism in Asia is a nationalism of confidence while nationalism in other places is a nationalism of insecurity’.
We have reached peak gene, and passed it.
Ken Richardson in "It's The End Of The Gene As We Know It"
In scientific, as well as popular descriptions today, genes “act,” “behave,” “direct,” “control,” “design,” “influence,” have “effects,” are “responsible for,” are “selfish,” and so on, as if minds of their own with designs and intentions.
But at the same time, a counter-narrative is building, not from the media but from inside science itself.... Scientists now understand that the information in the DNA code can only serve as a template for a protein. It cannot possibly serve as instructions for the more complex task of putting the proteins together into a fully functioning being, no more than the characters on a typewriter can produce a story....
First, laboratory experiments have shown how living forms probably flourished as “molecular soups” long before genes existed. They self-organized, synthesized polymers (like RNA and DNA), adapted, and reproduced through interactions among hundreds of components. That means they followed “instructions” arising from relations between components, according to current conditions, with no overall controller: compositional information, as the geneticist Doron Lancet calls it....
In this perspective, the genes evolved later, as products of prior systems, not as the original designers and controllers of them. More likely as templates for components as and when needed: a kind of facility for “just in time” supply of parts needed on a recurring basis.
We have traditionally thought of cell contents as servants to the DNA instructions. But, as the British biologist Denis Noble insists in an interview with the writer Suzan Mazur, “The modern synthesis has got causality in biology wrong … DNA on its own does absolutely nothing until activated by the rest of the system … DNA is not a cause in an active sense. I think it is better described as a passive data base which is used by the organism to enable it to make the proteins that it requires.”
A gene is a DNA sequence (whose component segments do not necessarily need to be physically contiguous) that specifies one or more sequence-related RNAs/proteins that are both evoked by Genetic Regulatory Networks and participate as elements in Genetic Regulatory Networks, often with indirect effects, or as outputs of Genetic Regulatory Networks, the latter yielding more direct phenotypic effects.Wiki tells us: A genetic regulatory network (GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell to govern the gene expressionlevels of mRNA and proteins.
| Sponsor: | Rep. Ocasio-Cortez, Alexandria [D-NY-14] (Introduced 02/07/2019) |
|---|---|
| Committees: | House - Energy and Commerce; Science, Space, and Technology; Education and Labor; Transportation and Infrastructure; Agriculture; Natural Resources; Foreign Affairs; Financial Services; Judiciary; Ways and Means; Oversight and Reform |
| Latest Action: | House - 02/12/2019 Referred to the Subcommittee on Energy and Mineral Resources. (All Actions) |
116th CONGRESS
1st Session |
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| Dholavira Seal from the Harappan Era. No implication that this is connected to the story below. I just like it as an illustration. |
Kaaryam kaarunyamaaryen na kashchit naaparaadhyati
(कार्यं कारुण्यमार्येण न कश्चिन्नापराध्यति) :
Showing kindness (towards the saintly and the sinner alike) defines a person as Arya for there is none who has never committed a wrong.
Valmiki Ramayana: Yuddha Kanda: 46
“Please imagine a ladder, with steps numbered from 0 at the bottom to 10 at the top. The top of the ladder represents the best possible life for you and the bottom of the ladder represents the worst possible life for you. On which step of the ladder would you say you personally feel you stand at this time?”The average for the country is supposed to reflect its level of happiness. The Cantril Life Ladder is available for India from 2006 onwards. The report also includes measures that one might think affects the answers given on the Cantril Life Ladder, such as per capita income and life expectancy, and survey measures such as perceived freedom to make life choices, perceived corruption, and so on. India is generally improving on these measures over the 2006-2018 time period. One interesting thing is that countries with poorer improvement on these measures can be happier than India.
For a graduate student it can be very difficult. It’s very easy to get discouraged if you have no real understanding that you’re going to be stuck for a very long time.from an interview with Akshay Venkatesh.
I could very easily have imagined myself getting discouraged and dropping out of graduate school. That could have easily happened to me under different circumstances.
Graduate school is a different environment and then you start to wonder—“Am I really good enough to do research-level math?” It’s hard, in fact, to tell. You see all these people who are doing great things around you and then you think, well, maybe you’re not cut out for this. So I think it’s important [long pause] to have someone who believes in you.
You could very justifiably say “look, you’re just continuing to make excuses for a paradigm that failed”, OK, and I would say that’s true, and even the paradigm most of your advisors love [e.g. usual SUSY] was already an excuse for the failure of non-supersymmetric GUTs before that.
That is a perfectly decent attitude to take, but I would like to at least tell you that you should study some of the history of physics. This very, very, very rarely happens, that some idea that seems basically right is just crap and wrong, It’s probably mostly right with a tweak or some reinterpretation. You’d have to go back over…, I don’t know how far you’d have to go back, even Ptolemy wasn’t so far from wrong…Ouch! That is some seriously bad reading of the history of physics. That was amply pointed out in the comments on the blog.
Stop picking on Nima. You all are doing the internet thing of taking one statement in an hour talk and ganging up.But challenged on it, he continued:
Even the pre-Copernican Ptolemaic stuff made sense to me. Basically, there are concepts in a failed theory that you might want to keep (things moving in circles around other things) and others you might want to jettison. Granted, he is not very good at history of science.Double Ouch! Is "things moving in circles around other things" a valuable idea from the Ptolemaic theory of the solar system? I think it is wrong on two counts -- firstly, the idea of things moving in circles around other things is present in earlier theories of the heavens; and secondly, things moving in circles around other things is not a theoretical idea; it is a root observation, the experience early humans had of the skies, at the very start of the study of the heavens. For example, the sun rises at the east horizon in the morning every day, sets at the west horizon in the evening and presumably somehow finds its way back in the dark to the east horizon the next morning, completing a closed loop if not a circle, per the early earth-bound humans.
As the nineteenth century came to an end, business and civic leaders across a number of West European and North American countries united to promote compulsory universal public education. But this posed a serious problem: how should a diverse population of children be educated?
....
The opportunity of a lifetime {for Binet} came in October 1904, when Joseph Chaumie, the {French} minister of public instruciton, established a commission to create a way to identify students in need of alternative education.....Binet and {Theodore} Simon immediately went to work.
....
Binet and Simon made clear the purpose of their test:
Our purpose is to be able to measure the intellectual capacity of a child who is brought to us in order to know whether he is normal or retarded. We should, therefore, study his condition at that time and that time only. We have nothing to do either with his past history or his future; consequently we shall neglect his etiology, and we shall make no attempt to distinguish between acquired and congenital idiocy...we do not attempt to establish or prepare a prognosis and we leave unanswered the question of whether this retardation is curable, or even improbable. We shall limit ourselves to ascertaining the truth about his present mental state.....
Along with their test, they also published a number of caveats. First, they made it clear that their test does not measure a person's absolute level of intelligence. They warned that their test couldn't possibly offer precise measurement like inches as measured by a ruler. Instead, a score on their test was simply a classification entirely relative to that of other children of the same age. ....
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Binet and Simon also acknowledged that many others than intellectual ability could influence performance on their tests, such as the unnaturalness of the testing situation and the potential for the test to intimidate children. They also mentioned longer term influences, such as background, upbringing, health and effort. Due to these other potential influences, they stressed the need to compare any person's test results only with those of comparable backgrounds. Finally, they noted the importance of constant retesting, pointing out that individuals' intellectual development progresses at variable rates, due to different rates of maturation as well as differences in intellectual experiences.
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It's noteworthy that the Binet-Simon scale never yielded an intelligence quotient (IQ). In fact, long after Binet's death, Simon indicated that the use of a summary IQ score was a betrayal of the purpose of their test. While Binet and Simon's purpose was noble, let's be absolutely clear: most people in France just wanted to weed out the intellectually disabled os that the "normal" students would not be slowed down.
....
Alas, Binet's efforts, caveats and cautions were almost completely ignored by the French establishment...Binet and Simon's efforts were wasted in their native France. Binet personally felt as though he was a failure.
Soon his test would spread like wildfire across the globe-- particularly in America-- and to his horror, his test was used for purposes he never intended. Toward the very end of his life, in response to statements that children with low test scores would never achieve certain things, he wrote in exasperation: "Never! What a strong word! A few modern philosphers seem to lend their moral support to the these deplorable verdicts when they assert that an individual's intelligence is a fixed quantity, a quantity which cannot be increased. We must protest and react against this brutal pessimism. We shall attempt to prove that it is without foundation... With practice, training , and above all method, we manage to increase our attention, our memory, our judgment and literally to become more intelligent than we were before."
Binet even developed various "mental orthopedics" -- intellectual exercises -- to show the potential for remediation. But it was too late. On October 28, 1911, Binet suffered a stroke and passed away at the young age of 54. The mass testing movement in America had just begun, with the testing proponents carrying with them a completely different conceptualization of human intelligence.
When our intelligence scales have become more accurate and the laws governing IQ changes have been more definitively established it will then be possible to say that there is nothing about an individual as important as his IQ, except possibly his morals; that the greatest educational problem is to determine the kind of education best suited to each IQ level; that the first concern of a nation should be the average IQ of its citizens, and the eugenic and dysgenic influences which are capable of raising or lowering that level; that the great test problem of democracy is how to adjust itself to the large IQ differences which can be demonstrated to exist among the members of any race or nationality group. — Lewis M. Terman (1922)
"Sorry losers and haters, but my I.Q. is one of the highest -and you all know it! Please don't feel so stupid or insecure,it's not your fault" (Donald J. Trump, May 8, 2013)
I hate the impudence of a claim that in fifty minutes you can judge and classify a human being’s predestined fitness in life. I hate the pretentiousness of that claim. I hate the abuse of scientific method which it involves. I hate the sense of superiority which it creates, and the sense of inferiority which it imposes. Walter Lippmann (1923)
But at start of the 21st century, researchers uncovered a harbinger for GR {gene recombination}. We discovered that DNA sequences vary from cell to cell, meaning that our brains are a vast mosaic of distinct genomes, a phenomenon aptly referred to as “genomic mosaicism.” These changes are distinct from epigenetic changes that do not directly affect DNA sequences. Scientists have now identified multiple sequence changes that are quite varied and seemingly random, consisting—in order of decreasing size—of entire chromosomes (aneuploidies), smaller copy number variations, even smaller LINE1 retrotransposon repeat elements and “single nucleotide variations that alter individual nucleotides.How genes determine IQ becomes a bit mysterious if "our brains are a vast mosaic of distinct genomes". One question presumably would be that are these "vast mosaic of distinct genomes in the brain" the same in some statistical sense in identical twins raised together and those raised separately?
"The test publishers were skeptical. Why take so much time to measure a person's intelligence? This was antithetical to America's obsession with a fast, cheap and efficient way to categorize the totality of a person".This leads to the question, why is America so obsessed? Is it a by-product of the ideology of capitalism?
We classify learning disabilities because children with dyslexia require very different academic support than children with Asperger's. In order to help these very different children, we must identify and understand their deficits and the resources those children will need. I have sat in on many meetings in which we - teams of psychologists, teachers, parents, learning specialists, and administrators - work to find the ideal combination of resources for kids with learning challenges. I have even recommended intelligence testing for students who, despite their persistence, diligence and effort, are not succeeding in school. I've seen testing lead to real academic and cognitive improvement, thanks to individualized education plans and access to learning resource professionals.But the article does say that IQ test results are not destiny, via the story of Scott Barry Kaufman.
Kaufman, writing of his experience in Ungifted: Intelligence Redefined. The Truth About Talent, Practice, Creativity, and the Many Paths to Greatness, may have thought he knew what was at stake when he visited that school psychologist for testing, but he would not fully grasp the influence that afternoon of testing would have on the trajectory of his life until much later. The psychologist who tested Kaufman concluded that he had a relatively low IQ, a score low enough to earn him the label "seriously learning disabled."Kaufman narrates:
After school I dash off to the local library and find a book about human intelligence. I flip through the pages and come face to face with a terrifying chart. At the top is listed the average IQ of PhDs. I am way lower than that number. Tentatively, I go down the list. College graduate? Closer, but still no cigar. My blood pressure is rising. Semiskilled laborer? In my dreams. After some time, I finally find my range: "Lucky to graduate high school," it says.But Kaufman "ripped up his label, held on tight to his growth mindset and his well-honed skills of grit, diligence, and persistence, and rode that potential all the way to a Ph.D from Yale."
“I suspect the I.Q., SAT, and school grades are tests designed by nerds so they can get high scores in order to call each other intelligent...Smart and wise people who score low on IQ tests, or patently intellectually defective ones, like the former U.S. president George
W. Bush, who score high on them (130), are testing the test and not the reverse.”
― Nassim Nicholas Taleb, The Bed of Procrustes: Philosophical and Practical Aphorisms