Canon Rumors 12 Days of Christmas – Day 10
3 hours ago
Partly collected thoughts.
With city finances rapidly recovering in California, I have noticed that many of the chewed up city streets in the SF Peninsula where I live are undergoing a transformation, and such was the case with mine.But this recovery is because California threw out the Republicans, ended an era of bad governance and fixed the state's finances. It is not at all clear that the nation as a whole is willing to do the same. The Republicans will hold on to the House of Representatives in 2014, it is almost mathematically impossible to dislodge them; and the Republicans are given a better than even chance of winning the Senate in the 2014 elections. The current set of Republicans are threatening to shut the government down, or even to force a default on its obligations by the Federal government (a default would put the world economy into a tailspin) in order to get their way.
Repudiating scientism, rather than surrendering to it....
Scientism is the idea that only science is the proper mode of human thought, and in particular, a blinkered, narrow notion that every human advance is the product of scientific, rational, empirical thinking. Much as I love science, and am personally a committed practitioner who also has a hard time shaking myself out of this path (I find scientific thinking very natural), I’ve got enough breadth in my education and current experience to recognize that there are other ways of progressing. Notice that I don’t use the phrase “ways of knowing” here — I have a rigorous enough expectation of what knowledge represents to reject other claims of knowledge outside of the empirical collection of information.....
It’s the curse of teaching at a liberal arts university and rubbing elbows with people in the arts and humanities all the time.
I probably know more about the biological side of how the brain functions than Pinker does, with my background in neuroscience, cell biology, and molecular biology. But I have no illusions. If I could travel in time to visit Hume or Spinoza, I might be able to deliver the occasional enlightening fact that they would find interesting, but most of my knowledge would be irrelevant to their concerns, while their ideas would have broader applicability and would enlighten me. When I imagine visiting these great contributors to the philosophy of science (Hume and Bacon would be at the top of my list), I see myself as a supplicant, hoping to learn more, not as the font of wisdom come to deliver them from their errors. Alright, I might argue some with them, but Jesus…they have their own domains of understanding in which they are acknowledged masters, domains in which I am only a dabbler.
In announcing on June 26, 2000, that the first draft of the human genome had been achieved, Mr. Clinton said it would “revolutionize the diagnosis, prevention and treatment of most, if not all, human diseases.”
At a news conference, Francis Collins, then the director of the genome agency at the National Institutes of Health, said that genetic diagnosis of diseases would be accomplished in 10 years and that treatments would start to roll out perhaps five years after that.
“Over the longer term, perhaps in another 15 or 20 years,” he added, “you will see a complete transformation in therapeutic medicine.”
The pharmaceutical industry has spent billions of dollars to reap genomic secrets and is starting to bring several genome-guided drugs to market. While drug companies continue to pour huge amounts of money into genome research, it has become clear that the genetics of most diseases are more complex than anticipated and that it will take many more years before new treatments may be able to transform medicine.
“Genomics is a way to do science, not medicine,” said Harold Varmus, president of the Memorial Sloan-Kettering Cancer Center in New York, who in July will become the director of the National Cancer Institute.
The last decade has brought a flood of discoveries of disease-causing mutations in the human genome. But with most diseases, the findings have explained only a small part of the risk of getting the disease. And many of the genetic variants linked to diseases, some scientists have begun to fear, could be statistical illusions.
The genes for IQ have never been found. Ironically, at the same time that genetics has ceased to be a popular explanation for human intellectual and temperamental differences, genetic theories for the causation of virtually every physical disorder have become the mode. “DNA” has replaced “IQ” as the abbreviation of social import. The announcement in February 2001 that two groups of investigators had sequenced the entire human genome was taken as the beginning of a new era in medicine, an era in which all diseases would be treated and cured by the replacement of faulty DNA. William Haseltine, the chairman of the board of the private company Human Genome Sciences, which participated in the genome project, assured us that “death is a series of preventable diseases.” Immortality, it appeared, was around the corner. For nearly ten years announcements of yet more genetic differences between diseased and healthy individuals were a regular occurrence in the pages of The New York Times and in leading general scientific publications like Science and Nature.
Then, on April 15, 2009, there appeared in The New York Times an article by the influential science reporter and fan of DNA research Nicholas Wade, under the headline “Study of Genes and Diseases at an Impasse.” In the same week the journal Science reported that DNA studies of disease causation had a “relatively low impact.” Both of these articles were instigated by several articles in The New England Journal of Medicine, which had come to the conclusion that the search for genes underlying common causes of mortality had so far yielded virtually nothing useful. The failure to find such genes continues and it seems likely that the search for the genes causing most common diseases will go the way of the search for the genes for IQ.
Yet it is remarkable how much important practical science has been quite independent of theory. In Chapter 3, I will consider one of the most famous examples of scientific agricultural change: the introduction of hybrid corn all over the world. Hybrid corn is said to be one of the great triumphs of modern genetics in action, helping to feed people and increase their well-being. Yet the development of hybrid corn and, indeed, almost all plant and animal breeding as it is actually practiced has been carried out in a way that is completely independent of any scientific theory. Indeed, a great deal of plant and animal breeding has been done in a way indistinguishable from the methods of past centuries before anyone had ever heard of genetics.Already by 1991, the first genetically modified crops were appearing. The number of drugs and disease treatments that have proceeded from at least some understanding of the fundamental biology involved have greatly increased. In that sense the above is now somewhat dated.
The same is true for our attempts to cope with killers like cancer and heart disease. Most cures for cancer involve either removing the growing tumor or destroying it with powerful radiation or chemicals. Virtually none of this progress in cancer therapy has occurred because of a deep understanding of the elementary processes of cell growth and development, although nearly all cancer research, above the purely clinical level, is devoted precisely to understanding the most intimate details of cell biology. Medicine remains, despite all the talk of scientific medicine, essentially an empirical process in which one does what works.
On the specific side, genetics, in particular, has for its entire history, since the beginning of the twentieth century, except for a very brief period during the Second World War, genetics has been extremely -- what shall I call it? -- deterministic in its view of the causes of human and social behavior. Geneticists have been, if you like, imperialistic in saying genes are responsible for everything.
While Mr. Herzog’s films are often ambiguous in nature, without a clear-cut editorial point, his message in this documentary is absolutely apparent. “Don’t ever text and drive.” Mr. Gerber says, “You get one chance, and you live with the choices you make.”The National Safety Council estimated that roughly 200,000 crashes in 2011 involved texting; and an AT&T Wireless survey found that 75 percent of teenagers say texting while driving is “common” among their friends. Whether or not Mr. Herzog’s film can actually reduce those figures, the project sets a high standard for how corporations can educate the public.
This is a repository of information on the Theory of Linear Structures (TLS) and a workspace for its further development. .....The Theory of Linear Structures is an alternative framework for describing physical geometry. It replaces the standard theory of point-set topology based on open sets with a version of point-set topology based on lines. ....The theory and its benefits are presented in Tim Maudlin's New Foundations for Physical Geometry, forthcoming from Oxford University Press.Of interest to anyone who wants to sink their teeth into TLS are these problem sets.
For almost the entire history of European society since the empire of Charlemagne, the chief institution of social legitimation was the Christian Church. It was by the grace of God that each person had an appointed place in society. Kings ruled Dei gratia. Occasionally divine grace could be conferred on a commoner who was ennobled, and grace could be removed. Grace was removed from King Charles I, as Cromwell noted, and the proof was Charles's severed head. Even the most revolutionary of religious leaders pressed the claims of legitimacy for the sake of order. Martin Luther enjoined his flock to obey their lords, and in his famous sermon on marriage he asserted that justice was made for the sake of peace and not peace for the sake of justice. Peace is the ultimate social good, and justice is important only if it subserves peace.
Fourth, I argued that Pinker minimized his debt to Enlightenment thought. One of his key claims in TBS {The Blank Slate} was that evolutionary psychology poses no threat to human decency. Another was that morality evolved. But I pointed out that the morality Pinker used at every turn to pacify evolutionary psychology was a product of Enlightenment liberalism, not evolution. Pinker now says that he is “the first to agree.” It’s too bad he couldn’t find room to agree in his 509-page book.Which is exactly also why I who rarely agree with Douthat agree with him here. I read Pinker as saying that common sense (some unexceptionable conviction) + science provides us an adequate moral system.
The facts of science, by exposing the absence of purpose in the laws governing the universe, force us to take responsibility for the welfare of ourselves, our species, and our planet. For the same reason, they undercut any moral or political system based on mystical forces, quests, destinies, dialectics, struggles, or messianic ages. And in combination with a few unexceptionable convictions— that all of us value our own welfare and that we are social beings who impinge on each other and can negotiate codes of conduct—the scientific facts militate toward a defensible morality, namely adhering to principles that maximize the flourishing of humans and other sentient beings. This humanism, which is inextricable from a scientific understanding of the world, is becoming the de facto morality of modern democracies, international organizations, and liberalizing religions, and its unfulfilled promises define the moral imperatives we face today.
In 1828, when causes of death were first systematically recorded in Britain, the death rate from tuberculosis was nearly 4,000 per million. The rate can only be appreciated in contrast to the present death rate in the US and Britain from all causes of only 9,000 per million. By 1855 the death rate from tuberculosis had fallen to about 2,700 and continued to fall steadily so that by the turn of the century it had reached about 1,200 per million. Koch’s discovery of the causal bacillus in the 1880s had no effect whatsoever on the rate of decline, and by 1925, after the Flexner revolution in medical schools, the rate was about 800, only 20 percent of its value in 1838. Totally unaffected by the arrival of modern medicine, the death rate continued its steady drop to 400 per million until 1948 when the introduction of chemotherapy on a broad scale did indeed accelerate the decline to its present negligible level. It is important to note that 57 percent of the decline had occurred by 1900 and 90 percent of the decline had occurred by the time of the introduction of chemotherapy. Extrapolation of the trend predicts that by 1970 death from tuberculosis would have reached its present low value even in the absence of chemotherapy.
The history of tuberculosis is the history of nearly all the major killers of the nineteenth century. Whooping cough, scarlet fever, and measles, all with death rates in excess of 1,000 per million children, and bronchitis, all declined steadily with no observable effect of the discovery of causative agents, of immunization or of chemotherapy. The sole exception was diphtheria which began its precipitous decline in 1900 with the introduction of anti-toxin and which was wiped out in five years after the national immunization campaign. The most revealing case is that of measles which killed about 1,200 in every million children in the nineteenth century. By 1960, despite the complete absence of any known medical treatment, it had disappeared as a cause of death in Britain and the US while in much of Africa it remains the chief cause of death of children.
The causes of the tremendous decline of mortality from infectious diseases in the last 100 years are not certain. All that is certain is that “scientific medicine” played no significant part. Water supply and sanitation are not involved, since water-borne diseases have not been the major killers. The suggestion that a reduction in crowding may have reduced the rate of transmission of respiratory diseases is not altogether convincing, since measles remains pandemic although it kills virtually no one in advanced countries. The most likely explanation, both for the historical trend and for the differences between regions of the world today, is in nutrition, although hard evidence is not easy to come by.
The real trouble with the Brain Initiative is not philosophical but practical. In short, the instrumental approach to the treatment of physiological and psychological diseases tends to be at odds with the traditional ways in which human beings have addressed their problems: that is, by talking and working with one another to the end of greater personal self-realization and social harmony.
In “Biology as Ideology,” Richard Lewontin points to the profound difference between the fact that one cannot get tuberculosis without a tubercle bacillus and the claim that the tubercle bacillus is the “cause” of tuberculosis. Registering that tuberculosis was a disease common in sweatshops in the 19th century, Lewontin contends: “We might be justified in claiming that the cause of tuberculosis is unregulated industrial capitalism, and if we did away with that system of social organization, we would not need to worry about the tubercle bacillus.” Having narrowed their view of “cause” to the biological realm, neuroscientists today are effectively chasing tubercle bacilli, drawing our focus away from the social practices and institutions that contribute to problems of mental health.
We know, for instance, that low socioeconomic status at birth is associated with a greater risk of developing schizophrenia, but the lion’s share of research into schizophrenia today is carried out by neurobiologists and geneticists, who are intent on uncovering the organic “cause” of the disease rather than looking into psychosocial factors. Though this research may very well bear fruit, its dominance over other forms of research, in the face of the known connection between poverty and schizophrenia, attests to a curious assumption that has settled into a comfortable obviousness: that socioeconomic status, unlike human biology, is something we cannot change “scientifically.” That it is somehow more realistic, “scientifically,” to find a way to change the human being itself than it is to work together to change the kind of environment that lends itself to the emergence of a disorder like schizophrenia.
What these cases show is that it is not Islam that makes young converts violent; it is the violence within them that causes them to convert to Islam. The religion, in its most bloodthirsty form, supplies all their psychological needs and channels their anger into a supposedly higher purpose. It gives them moral license to act upon their rage; for, like many in our society, they do not realize that anger is not self-justifying, that one is not necessarily right because one is angry, and that in any case even justified anger does not entail a license to act violently. The hacking to death of Lee Rigby on a street in Woolwich tells us as much about the society that we have created, or allowed to develop, as it does about radical Islam preached by fat, middle-aged clerics.
Far from being a revolutionary, the Buddha emphatically outed himself as a conservative, both in social and in religious matters. He was not a rebel or a revolutionary, but wanted the existing customs to continue.
In general, you needn’t be found guilty to have your assets claimed by law enforcement; in some states, suspicion on a par with “probable cause” is sufficient. Nor must you be charged with a crime, or even be accused of one. Unlike criminal forfeiture, which requires that a person be convicted of an offense before his or her property is confiscated, civil forfeiture amounts to a lawsuit filed directly against a possession, regardless of its owner’s guilt or innocence.and
Over the past year, I spoke with more than a hundred police officers, defense attorneys, prosecutors, judges, and forfeiture plaintiffs from across the country. Many expressed concern that state laws designed to go after high-flying crime lords are routinely targeting the workaday homes, cars, cash savings, and other belongings of innocent people who are never charged with a crime.Texas become Bihar, except that nobody in Bihar would pretend this is anything but corrupt. India has a reputation for corruption, but that sometimes seems to simply mean that practices that are legal in Texas are illegal in India. (It is not just Texas that uses these laws, but that state prides itself in protecting the untrammeled rights of a property owner to do whatever; it seems to be true only if the property owner is rich, powerful and connected.)